By far, safe mode is the most effective place to do any malware or virus repairs. With CCleaner, Malwarebytes - Antimalware, SuperAntiSpyware, and an Antivirus program all up-to-date, should give you a fighting chance. malware likes to hang out in the Doccuments and Settings/User folders, Temporary Internet Files folder, and the Windows System folder. With Windows in "Normal Mode" the malware detects all kinds of removal software and becomes stealth. You may see it and even be able to delete it from the Task Manager, it it has not been deactivated, but it will restart itself. If your Windows file search is still working, you can search all you want and not find the file. For the most part, while in safe mode, malware is visible and inactive, and a search will find the nasty files. Your anti-malware software will then see it and get rid of it. SuperAntiSpyware always has an up-to-date portable version for free download that can be placed on a USB device.
Good luck with your next crash!